Properties of the Michaelis-Menten equation and its integrated form which are useful in pharmacokinetics
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چکیده
منابع مشابه
ESTIMATING THE PARAMETERS OF THE MICHAElIS - MENTEN EQUATION USING SAS
The Michaelis-Menten equation, a rectangular hyperbola with two ~arameters ~o b~ specified, . occurs prominently 1n enzyme k,netlcs." Often, ~n consulting situations we need to (i) obtain estlmates standard errors, and confidence intervals for the unknown parameters, which define this nonlinear model for one set of experimental conditions and (ii) compare the parameter estimates under different...
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Many enzymatic reactions in biochemistry are far more complex than the celebrated Michaelis-Menten scheme, but the observed turnover rate often obeys the hyperbolic dependence on the substrate concentration, a relation established almost a century ago for the simple Michaelis-Menten mechanism. To resolve the longstanding puzzle, we apply the flux balance method to predict the functional form of...
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When the concentration dependence of an enzymic reaction or a transport process can be described by the sum of two Michaelis-Menten terms, reliable data that relate reaction rate and substrate concentration can be obtained even when as much as 70 per cent of substrate was consumed during the assay. Each data pair consists of the average reaction rate during an assay and the concentration where ...
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Accuracy of analytical-numerical solutions of the Michaelis-Menten equation
It is the aim of this paper to investigate a suitable approach to compute solutions of the powerful Michaelis-Menten enzyme reaction equation with less computational effort. We obtain analytical-numerical solutions using piecewise finite series by means of the differential transformation method, DTM. In addition, we compute a global analytical solution by a modal series expansion. The Michaelis...
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ژورنال
عنوان ژورنال: Journal of Pharmacokinetics and Biopharmaceutics
سال: 1973
ISSN: 0090-466X
DOI: 10.1007/bf01059625